O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 S 19 0 19 0.108 0.243 View mutations
152 E 12 7 19 0.377 0.410 View mutations
153 L 19 0 19 0.049 0.230 View mutations
154 I 17 2 19 0.128 0.344 View mutations
155 L 18 1 19 0.153 0.246 View mutations
156 A 13 6 19 0.363 0.427 View mutations
157 Q 18 1 19 0.063 0.320 View mutations
158 Q 10 9 19 0.477 0.491 View mutations
159 Q 8 11 19 0.537 0.517 View mutations
160 Q 16 3 19 0.247 0.419 View mutations
161 H 17 2 19 0.158 0.400 View mutations
162 K 5 14 19 0.634 0.581 View mutations
163 K 11 8 19 0.437 0.480 View mutations
164 Y 16 3 19 0.202 0.412 View mutations
165 H 19 0 19 0.044 0.331 View mutations
166 G 19 0 19 0.061 0.214 View mutations
167 S 19 0 19 0.047 0.186 View mutations
168 Q 19 0 19 0.026 0.381 View mutations
169 V 19 0 19 0.058 0.282 View mutations
170 Y 19 0 19 0.010 0.266 View mutations
171 V 19 0 19 0.004 0.198 View mutations
172 T 19 0 19 0.004 0.200 View mutations
173 F 19 0 19 0.005 0.155 View mutations
174 A 19 0 19 0.002 0.189 View mutations
175 V 17 2 19 0.152 0.257 View mutations