P10415 (BCL2)

Overview
Predicted structure (AF):
AF-P10415-F1-model_v4
Uniprot entry:
P10415
Gene:
BCL2
Protein length:
239 residues
Mutations found:
4540
Benign based on D2Deep prediction:
3113 out of 4540 mutations
Pathogenic based on D2Deep prediction:
1427 out of 4540 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4540 mutations across 239 unique positions. There are 3113 benign and 1427 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 0 18 18 0.902 0.564 View mutations
2 A 4 15 19 0.764 0.538 View mutations
3 H 1 18 19 0.935 0.406 View mutations
4 A 11 8 19 0.473 0.458 View mutations
5 G 15 4 19 0.258 0.492 View mutations
6 R 19 0 19 0.005 0.531 View mutations
7 T 19 0 19 0.011 0.499 View mutations
8 G 19 0 19 0.031 0.376 View mutations
9 Y 19 0 19 0.046 0.456 View mutations
10 D 19 0 19 0.047 0.475 View mutations
11 N 19 0 19 0.005 0.428 View mutations
12 R 4 15 19 0.732 0.571 View mutations
13 E 17 2 19 0.142 0.375 View mutations
14 I 17 2 19 0.281 0.324 View mutations
15 V 13 6 19 0.287 0.408 View mutations
16 M 18 1 19 0.047 0.395 View mutations
17 K 6 13 19 0.654 0.556 View mutations
18 Y 2 17 19 0.882 0.714 View mutations
19 I 4 15 19 0.762 0.642 View mutations
20 H 17 2 19 0.140 0.384 View mutations
21 Y 2 17 19 0.898 0.674 View mutations
22 K 5 14 19 0.734 0.641 View mutations
23 L 6 13 19 0.606 0.607 View mutations
24 S 3 16 19 0.692 0.636 View mutations
25 Q 0 19 19 0.991 0.666 View mutations