P10415 (BCL2)

Overview
Predicted structure (AF):
AF-P10415-F1-model_v4
Uniprot entry:
P10415
Gene:
BCL2
Protein length:
239 residues
Mutations found:
4540
Benign based on D2Deep prediction:
3113 out of 4540 mutations
Pathogenic based on D2Deep prediction:
1427 out of 4540 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4540 mutations across 239 unique positions. There are 3113 benign and 1427 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 S 14 5 19 0.289 0.689 View mutations
52 Q 16 3 19 0.162 0.810 View mutations
53 P 13 6 19 0.362 0.652 View mutations
54 G 18 1 19 0.098 0.876 View mutations
55 H 19 0 19 0.016 0.950 View mutations
56 T 19 0 19 0.001 0.982 View mutations
57 P 19 0 19 0.002 0.966 View mutations
58 H 19 0 19 0.015 0.928 View mutations
59 P 19 0 19 0.010 0.963 View mutations
60 A 19 0 19 0.004 0.938 View mutations
61 A 19 0 19 0.007 0.975 View mutations
62 S 19 0 19 0.022 0.930 View mutations
63 R 19 0 19 0.005 0.964 View mutations
64 D 18 1 19 0.051 0.913 View mutations
65 P 19 0 19 0.014 0.977 View mutations
66 V 17 2 19 0.143 0.861 View mutations
67 A 19 0 19 0.007 0.917 View mutations
68 R 19 0 19 0.015 0.909 View mutations
69 T 19 0 19 0.002 0.919 View mutations
70 S 19 0 19 0.001 0.881 View mutations
71 P 19 0 19 0.027 0.927 View mutations
72 L 19 0 19 0.006 0.965 View mutations
73 Q 19 0 19 0.002 0.949 View mutations
74 T 19 0 19 0.004 1.000 View mutations
75 P 19 0 19 0.007 0.980 View mutations