P10415 (BCL2)

Overview
Predicted structure (AF):
AF-P10415-F1-model_v4
Uniprot entry:
P10415
Gene:
BCL2
Protein length:
239 residues
Mutations found:
4540
Benign based on D2Deep prediction:
3113 out of 4540 mutations
Pathogenic based on D2Deep prediction:
1427 out of 4540 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4540 mutations across 239 unique positions. There are 3113 benign and 1427 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 R 14 5 19 0.257 0.414 View mutations
27 G 6 13 19 0.650 0.569 View mutations
28 Y 6 13 19 0.742 0.532 View mutations
29 E 5 14 19 0.729 0.510 View mutations
30 W 8 11 19 0.522 0.435 View mutations
31 D 17 2 19 0.112 0.477 View mutations
32 A 19 0 19 0.011 0.637 View mutations
33 G 17 2 19 0.139 0.606 View mutations
34 D 19 0 19 0.011 0.667 View mutations
35 V 19 0 19 0.010 0.758 View mutations
36 G 19 0 19 0.003 0.815 View mutations
37 A 19 0 19 0.001 0.844 View mutations
38 A 18 1 19 0.128 0.818 View mutations
39 P 14 5 19 0.277 0.638 View mutations
40 P 19 0 19 0.009 0.871 View mutations
41 G 19 0 19 0.018 0.838 View mutations
42 A 19 0 19 0.017 0.858 View mutations
43 A 19 0 19 0.010 0.890 View mutations
44 P 19 0 19 0.043 0.849 View mutations
45 A 16 3 19 0.252 0.742 View mutations
46 P 19 0 19 0.006 0.909 View mutations
47 G 19 0 19 0.005 0.856 View mutations
48 I 19 0 19 0.021 0.875 View mutations
49 F 19 0 19 0.058 0.909 View mutations
50 S 15 4 19 0.253 0.732 View mutations