P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 G 6 13 19 0.670 0.563 View mutations
202 C 19 0 19 0.003 0.248 View mutations
203 I 19 0 19 0.000 0.293 View mutations
204 F 19 0 19 0.000 0.533 View mutations
205 A 5 14 19 0.736 0.524 View mutations
206 E 0 19 19 0.947 0.644 View mutations
207 M 1 18 19 0.942 0.500 View mutations
208 F 8 11 19 0.634 0.432 View mutations
209 R 14 5 19 0.363 0.478 View mutations
210 R 19 0 19 0.014 0.358 View mutations
211 K 19 0 19 0.019 0.400 View mutations
212 P 1 18 19 0.969 0.558 View mutations
213 L 2 17 19 0.924 0.582 View mutations
214 F 0 19 19 0.992 0.486 View mutations
215 C 18 1 19 0.095 0.467 View mutations
216 G 3 16 19 0.864 0.563 View mutations
217 N 19 0 19 0.002 0.536 View mutations
218 S 2 17 19 0.796 0.504 View mutations
219 E 19 0 19 0.119 0.469 View mutations
220 A 19 0 19 0.003 0.397 View mutations
221 D 19 0 19 0.005 0.454 View mutations
222 Q 2 17 19 0.910 0.654 View mutations
223 L 19 0 19 0.001 0.319 View mutations
224 G 18 1 19 0.038 0.526 View mutations
225 K 15 4 19 0.297 0.492 View mutations