P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 R 16 3 19 0.167 0.427 View mutations
102 T 19 0 19 0.039 0.482 View mutations
103 Y 17 2 19 0.133 0.434 View mutations
104 L 1 18 19 0.942 0.626 View mutations
105 D 4 15 19 0.817 0.512 View mutations
106 K 18 1 19 0.040 0.500 View mutations
107 A 19 0 19 0.010 0.511 View mutations
108 P 13 6 19 0.357 0.462 View mutations
109 P 19 0 19 0.019 0.602 View mutations
110 P 19 0 19 0.006 0.520 View mutations
111 G 19 0 19 0.109 0.454 View mutations
112 L 10 9 19 0.524 0.493 View mutations
113 P 19 0 19 0.000 0.437 View mutations
114 A 18 1 19 0.074 0.543 View mutations
115 E 18 1 19 0.059 0.592 View mutations
116 T 19 0 19 0.022 0.490 View mutations
117 I 8 11 19 0.541 0.512 View mutations
118 K 19 0 19 0.010 0.558 View mutations
119 D 19 0 19 0.055 0.519 View mutations
120 L 19 0 19 0.008 0.427 View mutations
121 M 13 6 19 0.251 0.439 View mutations
122 R 19 0 19 0.001 0.676 View mutations
123 Q 12 7 19 0.395 0.497 View mutations
124 F 2 17 19 0.827 0.448 View mutations
125 L 8 11 19 0.621 0.435 View mutations