P15976 (GATA1)

Overview
Predicted structure (AF):
AF-P15976-F1-model_v4
Uniprot entry:
P15976
Gene:
GATA1
Protein length:
413 residues
Mutations found:
7846
Benign based on D2Deep prediction:
3634 out of 7846 mutations
Pathogenic based on D2Deep prediction:
4212 out of 7846 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 7846 mutations across 413 unique positions. There are 3634 benign and 4212 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
376 V 11 8 19 0.439 0.493 View mutations
377 S 11 8 19 0.433 0.488 View mutations
378 H 0 19 19 0.945 0.584 View mutations
379 L 2 17 19 0.870 0.541 View mutations
380 M 3 16 19 0.827 0.526 View mutations
381 P 1 18 19 0.906 0.521 View mutations
382 F 0 19 19 0.852 0.582 View mutations
383 P 4 15 19 0.809 0.429 View mutations
384 G 14 5 19 0.311 0.479 View mutations
385 P 9 10 19 0.466 0.432 View mutations
386 L 4 15 19 0.779 0.507 View mutations
387 L 8 11 19 0.629 0.501 View mutations
388 G 16 3 19 0.191 0.402 View mutations
389 S 7 12 19 0.546 0.418 View mutations
390 P 18 1 19 0.142 0.593 View mutations
391 T 17 2 19 0.109 0.608 View mutations
392 G 17 2 19 0.159 0.591 View mutations
393 S 17 2 19 0.084 0.548 View mutations
394 F 18 1 19 0.104 0.508 View mutations
395 P 19 0 19 0.003 0.623 View mutations
396 T 18 1 19 0.077 0.645 View mutations
397 G 17 2 19 0.122 0.546 View mutations
398 P 17 2 19 0.137 0.641 View mutations
399 M 17 2 19 0.107 0.628 View mutations
400 P 5 14 19 0.680 0.380 View mutations