P15976 (GATA1)

Overview
Predicted structure (AF):
AF-P15976-F1-model_v4
Uniprot entry:
P15976
Gene:
GATA1
Protein length:
413 residues
Mutations found:
7846
Benign based on D2Deep prediction:
3634 out of 7846 mutations
Pathogenic based on D2Deep prediction:
4212 out of 7846 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 7846 mutations across 413 unique positions. There are 3634 benign and 4212 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
351 S 16 3 19 0.170 0.605 View mutations
352 G 11 8 19 0.371 0.467 View mutations
353 L 5 14 19 0.700 0.403 View mutations
354 T 17 2 19 0.212 0.573 View mutations
355 L 15 4 19 0.264 0.538 View mutations
356 G 18 1 19 0.080 0.576 View mutations
357 P 19 0 19 0.049 0.659 View mutations
358 P 14 5 19 0.280 0.593 View mutations
359 G 14 5 19 0.287 0.586 View mutations
360 T 15 4 19 0.218 0.574 View mutations
361 A 16 3 19 0.181 0.543 View mutations
362 H 12 7 19 0.389 0.456 View mutations
363 L 7 12 19 0.632 0.429 View mutations
364 Y 1 18 19 0.908 0.473 View mutations
365 Q 10 9 19 0.435 0.440 View mutations
366 G 14 5 19 0.320 0.480 View mutations
367 L 0 19 19 0.930 0.490 View mutations
368 G 0 19 19 0.924 0.518 View mutations
369 P 6 13 19 0.618 0.515 View mutations
370 V 12 7 19 0.375 0.499 View mutations
371 V 14 5 19 0.323 0.468 View mutations
372 L 10 9 19 0.511 0.494 View mutations
373 S 7 12 19 0.654 0.443 View mutations
374 G 3 16 19 0.739 0.543 View mutations
375 P 9 10 19 0.495 0.501 View mutations