P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 Q 7 12 19 0.616 0.420 View mutations
77 A 13 6 19 0.320 0.537 View mutations
78 D 4 15 19 0.713 0.311 View mutations
79 S 9 10 19 0.487 0.448 View mutations
80 Q 9 10 19 0.491 0.445 View mutations
81 V 12 7 19 0.390 0.490 View mutations
82 T 8 11 19 0.481 0.432 View mutations
83 E 18 1 19 0.158 0.484 View mutations
84 V 17 2 19 0.219 0.422 View mutations
85 C 14 5 19 0.325 0.490 View mutations
86 A 19 0 19 0.002 0.487 View mutations
87 A 18 1 19 0.098 0.536 View mutations
88 T 19 0 19 0.004 0.503 View mutations
89 Y 19 0 19 0.045 0.555 View mutations
90 M 19 0 19 0.000 0.678 View mutations
91 M 19 0 19 0.000 0.615 View mutations
92 G 19 0 19 0.001 0.588 View mutations
93 N 19 0 19 0.017 0.683 View mutations
94 E 19 0 19 0.014 0.508 View mutations
95 L 9 10 19 0.533 0.443 View mutations
96 T 18 1 19 0.077 0.565 View mutations
97 F 17 2 19 0.148 0.476 View mutations
98 L 19 0 19 0.081 0.508 View mutations
99 D 18 1 19 0.108 0.537 View mutations
100 D 19 0 19 0.009 0.638 View mutations