P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 L 19 0 19 0.012 0.285 View mutations
127 Y 3 16 19 0.772 0.630 View mutations
128 I 14 5 19 0.272 0.399 View mutations
129 C 17 2 19 0.338 0.230 View mutations
130 K 1 18 19 0.955 0.657 View mutations
131 V 5 14 19 0.637 0.668 View mutations
132 E 0 19 19 0.984 0.873 View mutations
133 L 5 14 19 0.752 0.611 View mutations
134 M 10 9 19 0.474 0.483 View mutations
135 Y 5 14 19 0.695 0.632 View mutations
136 P 8 11 19 0.624 0.560 View mutations
137 P 1 18 19 0.822 0.858 View mutations
138 P 0 19 19 0.907 0.855 View mutations
139 Y 2 17 19 0.889 0.696 View mutations
140 Y 3 16 19 0.819 0.564 View mutations
141 L 16 3 19 0.227 0.397 View mutations
142 G 18 1 19 0.130 0.337 View mutations
143 I 18 1 19 0.041 0.454 View mutations
144 G 19 0 19 0.012 0.122 View mutations
145 N 19 0 19 0.081 0.244 View mutations
146 G 19 0 19 0.000 0.201 View mutations
147 T 18 1 19 0.068 0.079 View mutations
148 Q 19 0 19 0.004 0.224 View mutations
149 I 16 3 19 0.254 0.168 View mutations
150 Y 19 0 19 0.027 0.207 View mutations