P21912 (SDHB)

Overview
Predicted structure (AF):
AF-P21912-F1-model_v4
Uniprot entry:
P21912
Gene:
SDHB
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
3093 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2226 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 3093 benign and 2226 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 F 18 1 19 0.061 0.533 View mutations
227 T 19 0 19 0.000 0.479 View mutations
228 E 19 0 19 0.014 0.600 View mutations
229 E 3 16 19 0.822 0.414 View mutations
230 R 1 18 19 0.940 0.556 View mutations
231 L 19 0 19 0.004 0.489 View mutations
232 A 19 0 19 0.014 0.523 View mutations
233 K 16 3 19 0.219 0.531 View mutations
234 L 1 18 19 0.941 0.576 View mutations
235 Q 19 0 19 0.020 0.377 View mutations
236 D 19 0 19 0.013 0.357 View mutations
237 P 5 14 19 0.738 0.457 View mutations
238 F 5 14 19 0.723 0.516 View mutations
239 S 5 14 19 0.747 0.525 View mutations
240 L 7 12 19 0.581 0.557 View mutations
241 Y 15 4 19 0.250 0.394 View mutations
242 R 3 16 19 0.809 0.668 View mutations
243 C 8 11 19 0.611 0.548 View mutations
244 H 19 0 19 0.003 0.259 View mutations
245 T 3 16 19 0.872 0.669 View mutations
246 I 0 19 19 0.992 0.808 View mutations
247 M 19 0 19 0.002 0.398 View mutations
248 N 1 18 19 0.973 0.612 View mutations
249 C 0 19 19 1.000 0.776 View mutations
250 T 5 14 19 0.752 0.564 View mutations