P21912 (SDHB)

Overview
Predicted structure (AF):
AF-P21912-F1-model_v4
Uniprot entry:
P21912
Gene:
SDHB
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
3093 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2226 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 3093 benign and 2226 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 K 18 1 19 0.069 0.717 View mutations
52 A 18 1 19 0.064 0.605 View mutations
53 G 9 10 19 0.520 0.450 View mutations
54 D 18 1 19 0.077 0.590 View mutations
55 K 19 0 19 0.000 0.529 View mutations
56 P 3 16 19 0.816 0.510 View mutations
57 H 19 0 19 0.018 0.566 View mutations
58 M 18 1 19 0.090 0.581 View mutations
59 Q 19 0 19 0.019 0.417 View mutations
60 T 17 2 19 0.089 0.646 View mutations
61 Y 11 8 19 0.406 0.418 View mutations
62 E 15 4 19 0.216 0.614 View mutations
63 V 19 0 19 0.054 0.403 View mutations
64 D 18 1 19 0.088 0.571 View mutations
65 L 18 1 19 0.056 0.435 View mutations
66 N 19 0 19 0.010 0.575 View mutations
67 K 17 2 19 0.164 0.603 View mutations
68 C 7 12 19 0.635 0.501 View mutations
69 G 19 0 19 0.006 0.468 View mutations
70 P 17 2 19 0.092 0.430 View mutations
71 M 1 18 19 0.932 0.544 View mutations
72 V 2 17 19 0.860 0.572 View mutations
73 L 0 19 19 1.000 0.687 View mutations
74 D 0 19 19 0.981 0.593 View mutations
75 A 4 15 19 0.780 0.512 View mutations