P21912 (SDHB)

Overview
Predicted structure (AF):
AF-P21912-F1-model_v4
Uniprot entry:
P21912
Gene:
SDHB
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
3093 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2226 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5319 mutations across 280 unique positions. There are 3093 benign and 2226 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 L 1 18 19 0.951 0.570 View mutations
77 I 13 6 19 0.406 0.400 View mutations
78 K 3 16 19 0.857 0.344 View mutations
79 I 3 16 19 0.859 0.551 View mutations
80 K 0 19 19 0.999 0.676 View mutations
81 N 2 17 19 0.894 0.470 View mutations
82 E 2 17 19 0.875 0.371 View mutations
83 V 9 10 19 0.456 0.430 View mutations
84 D 13 6 19 0.467 0.431 View mutations
85 S 10 9 19 0.479 0.496 View mutations
86 T 9 10 19 0.538 0.513 View mutations
87 L 1 18 19 0.963 0.689 View mutations
88 T 4 15 19 0.790 0.620 View mutations
89 F 6 13 19 0.659 0.584 View mutations
90 R 0 19 19 0.961 0.891 View mutations
91 R 0 19 19 0.998 0.874 View mutations
92 S 19 0 19 0.000 0.051 View mutations
93 C 1 18 19 0.967 0.841 View mutations
94 R 0 19 19 0.985 0.930 View mutations
95 E 0 19 19 1.000 0.974 View mutations
96 G 0 19 19 1.000 1.000 View mutations
97 I 1 18 19 0.947 0.881 View mutations
98 C 1 18 19 0.940 0.853 View mutations
99 G 0 19 19 1.000 0.946 View mutations
100 S 0 19 19 1.000 0.861 View mutations