P31749 (AKT1)

Overview
Predicted structure (AF):
AF-P31749-F1-model_v4
Uniprot entry:
P31749
Gene:
AKT1
Protein length:
480 residues
Mutations found:
9119
Benign based on D2Deep prediction:
5131 out of 9119 mutations
Pathogenic based on D2Deep prediction:
3988 out of 9119 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9119 mutations across 480 unique positions. There are 5131 benign and 3988 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 Y 6 13 19 0.644 0.445 View mutations
27 F 19 0 19 0.024 0.461 View mutations
28 L 18 1 19 0.119 0.548 View mutations
29 L 18 1 19 0.096 0.408 View mutations
30 K 17 2 19 0.181 0.608 View mutations
31 N 19 0 19 0.001 0.586 View mutations
32 D 17 2 19 0.118 0.457 View mutations
33 G 0 19 19 0.940 0.517 View mutations
34 T 17 2 19 0.154 0.477 View mutations
35 F 3 16 19 0.808 0.517 View mutations
36 I 19 0 19 0.029 0.460 View mutations
37 G 16 3 19 0.227 0.458 View mutations
38 Y 1 18 19 0.918 0.444 View mutations
39 K 1 18 19 0.901 0.481 View mutations
40 E 17 2 19 0.172 0.519 View mutations
41 R 11 8 19 0.400 0.484 View mutations
42 P 19 0 19 0.014 0.646 View mutations
43 Q 19 0 19 0.000 0.746 View mutations
44 D 19 0 19 0.002 0.760 View mutations
45 V 16 3 19 0.154 0.688 View mutations
46 D 19 0 19 0.030 0.728 View mutations
47 Q 19 0 19 0.006 0.783 View mutations
48 R 19 0 19 0.007 0.791 View mutations
49 E 19 0 19 0.036 0.678 View mutations
50 A 12 7 19 0.328 0.527 View mutations