P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 E 19 0 19 0.003 0.928 View mutations
27 E 19 0 19 0.001 1.000 View mutations
28 D 19 0 19 0.010 0.966 View mutations
29 G 16 3 19 0.215 0.835 View mutations
30 G 19 0 19 0.013 0.955 View mutations
31 E 19 0 19 0.001 0.922 View mutations
32 E 19 0 19 0.000 0.955 View mutations
33 S 19 0 19 0.006 0.988 View mutations
34 G 18 1 19 0.088 0.946 View mutations
35 A 19 0 19 0.004 0.955 View mutations
36 E 19 0 19 0.001 0.913 View mutations
37 E 19 0 19 0.001 0.912 View mutations
38 S 19 0 19 0.020 0.955 View mutations
39 G 13 6 19 0.308 0.655 View mutations
40 P 18 1 19 0.079 0.899 View mutations
41 E 19 0 19 0.004 0.903 View mutations
42 E 19 0 19 0.000 0.892 View mutations
43 S 19 0 19 0.011 0.949 View mutations
44 G 19 0 19 0.026 0.909 View mutations
45 P 18 1 19 0.074 0.909 View mutations
46 E 19 0 19 0.011 0.916 View mutations
47 E 19 0 19 0.001 0.931 View mutations
48 L 17 2 19 0.119 0.854 View mutations
49 G 16 3 19 0.202 0.791 View mutations
50 A 15 4 19 0.300 0.786 View mutations