P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 E 7 12 19 0.541 0.369 View mutations
52 E 15 4 19 0.191 0.768 View mutations
53 E 17 2 19 0.161 0.809 View mutations
54 M 18 1 19 0.162 0.923 View mutations
55 E 19 0 19 0.009 0.785 View mutations
56 A 18 1 19 0.098 0.725 View mutations
57 G 4 15 19 0.672 0.359 View mutations
58 R 18 1 19 0.136 0.725 View mutations
59 P 18 1 19 0.072 0.615 View mutations
60 R 18 1 19 0.153 0.615 View mutations
61 P 10 9 19 0.450 0.445 View mutations
62 V 9 10 19 0.591 0.437 View mutations
63 L 15 4 19 0.276 0.474 View mutations
64 R 5 14 19 0.680 0.502 View mutations
65 S 17 2 19 0.164 0.381 View mutations
66 V 18 1 19 0.107 0.359 View mutations
67 N 7 12 19 0.695 0.543 View mutations
68 S 8 11 19 0.598 0.535 View mutations
69 R 18 1 19 0.052 0.378 View mutations
70 E 12 7 19 0.413 0.436 View mutations
71 P 3 16 19 0.751 0.685 View mutations
72 S 4 15 19 0.785 0.648 View mutations
73 Q 0 19 19 0.996 0.674 View mutations
74 V 0 19 19 0.959 0.868 View mutations
75 I 4 15 19 0.756 0.652 View mutations