P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
351 V 1 18 19 0.947 0.707 View mutations
352 T 0 19 19 0.997 0.684 View mutations
353 R 0 19 19 1.000 0.599 View mutations
354 H 0 19 19 0.999 0.597 View mutations
355 Y 2 17 19 0.898 0.512 View mutations
356 R 11 8 19 0.417 0.461 View mutations
357 E 18 1 19 0.097 0.643 View mutations
358 H 1 18 19 0.949 0.466 View mutations
359 Q 5 14 19 0.689 0.440 View mutations
360 K 19 0 19 0.003 0.742 View mutations
361 G 6 13 19 0.655 0.452 View mutations
362 R 18 1 19 0.073 0.723 View mutations
363 P 3 16 19 0.839 0.387 View mutations
364 T 0 19 19 1.000 0.697 View mutations
365 S 4 15 19 0.787 0.648 View mutations
366 T 0 19 19 0.963 0.751 View mutations
367 N 3 16 19 0.859 0.634 View mutations
368 P 1 18 19 0.966 0.676 View mutations
369 I 8 11 19 0.629 0.532 View mutations
370 A 18 1 19 0.118 0.218 View mutations
371 S 3 16 19 0.832 0.672 View mutations
372 I 14 5 19 0.331 0.400 View mutations
373 F 1 18 19 0.912 0.567 View mutations
374 A 2 17 19 0.846 0.644 View mutations
375 W 1 18 19 0.932 0.678 View mutations