P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
101 A 19 0 19 0.004 0.373 View mutations
102 L 17 2 19 0.116 0.620 View mutations
103 A 10 9 19 0.470 0.442 View mutations
104 T 2 17 19 0.888 0.470 View mutations
105 Q 15 4 19 0.222 0.482 View mutations
106 K 18 1 19 0.050 0.631 View mutations
107 Y 19 0 19 0.016 0.523 View mutations
108 S 4 15 19 0.749 0.467 View mutations
109 V 3 16 19 0.854 0.688 View mutations
110 A 1 18 19 0.944 0.686 View mutations
111 V 1 18 19 0.946 0.733 View mutations
112 K 2 17 19 0.889 0.779 View mutations
113 C 7 12 19 0.660 0.595 View mutations
114 A 3 16 19 0.843 0.776 View mutations
115 T 0 19 19 1.000 0.943 View mutations
116 I 0 19 19 0.983 0.840 View mutations
117 T 2 17 19 0.906 0.693 View mutations
118 P 19 0 19 0.002 0.223 View mutations
119 D 16 3 19 0.170 0.418 View mutations
120 E 19 0 19 0.005 0.494 View mutations
121 A 16 3 19 0.208 0.533 View mutations
122 R 3 16 19 0.811 0.639 View mutations
123 V 0 19 19 0.985 0.657 View mutations
124 E 18 1 19 0.092 0.656 View mutations
125 E 0 19 19 0.969 0.487 View mutations