P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 L 13 6 19 0.263 0.454 View mutations
27 E 19 0 19 0.012 0.530 View mutations
28 E 14 5 19 0.335 0.427 View mutations
29 W 0 19 19 0.987 0.525 View mutations
30 Q 17 2 19 0.153 0.524 View mutations
31 D 19 0 19 0.001 0.698 View mutations
32 K 16 3 19 0.230 0.467 View mutations
33 W 0 19 19 1.000 0.484 View mutations
34 V 18 1 19 0.062 0.545 View mutations
35 N 18 1 19 0.078 0.701 View mutations
36 G 19 0 19 0.052 0.554 View mutations
37 K 18 1 19 0.075 0.552 View mutations
38 T 4 15 19 0.740 0.447 View mutations
39 A 6 13 19 0.721 0.437 View mutations
40 F 10 9 19 0.491 0.422 View mutations
41 H 1 18 19 0.921 0.531 View mutations
42 Q 19 0 19 0.016 0.468 View mutations
43 E 19 0 19 0.000 0.481 View mutations
44 Q 11 8 19 0.403 0.481 View mutations
45 G 0 19 19 0.968 0.468 View mutations
46 H 11 8 19 0.454 0.424 View mutations
47 Q 19 0 19 0.045 0.554 View mutations
48 L 4 15 19 0.726 0.438 View mutations
49 L 0 19 19 0.930 0.650 View mutations
50 K 1 18 19 0.961 0.428 View mutations