P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 K 0 19 19 1.000 0.330 View mutations
52 H 1 18 19 0.936 0.409 View mutations
53 L 3 16 19 0.839 0.553 View mutations
54 D 5 14 19 0.636 0.434 View mutations
55 T 19 0 19 0.000 0.521 View mutations
56 F 15 4 19 0.202 0.387 View mutations
57 L 2 17 19 0.881 0.461 View mutations
58 K 19 0 19 0.032 0.652 View mutations
59 G 12 7 19 0.390 0.445 View mutations
60 K 18 1 19 0.070 0.628 View mutations
61 S 19 0 19 0.046 0.591 View mutations
62 G 4 15 19 0.723 0.427 View mutations
63 L 8 11 19 0.580 0.513 View mutations
64 R 18 1 19 0.101 0.485 View mutations
65 V 5 14 19 0.638 0.562 View mutations
66 F 5 14 19 0.735 0.621 View mutations
67 F 0 19 19 1.000 0.803 View mutations
68 P 0 19 19 1.000 0.962 View mutations
69 L 1 18 19 0.930 0.744 View mutations
70 C 1 18 19 0.936 0.942 View mutations
71 G 0 19 19 0.994 1.000 View mutations
72 K 0 19 19 0.999 0.802 View mutations
73 A 0 19 19 1.000 0.819 View mutations
74 V 1 18 19 0.951 0.746 View mutations
75 E 0 19 19 0.999 0.745 View mutations