P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 M 0 19 19 1.000 0.839 View mutations
77 K 1 18 19 0.943 0.659 View mutations
78 W 0 19 19 1.000 0.606 View mutations
79 F 1 18 19 0.963 0.716 View mutations
80 A 0 19 19 1.000 0.802 View mutations
81 D 0 19 19 1.000 0.703 View mutations
82 R 3 16 19 0.860 0.553 View mutations
83 G 0 19 19 1.000 0.760 View mutations
84 H 0 19 19 0.990 0.749 View mutations
85 S 17 2 19 0.187 0.454 View mutations
86 V 3 16 19 0.788 0.686 View mutations
87 V 7 12 19 0.545 0.537 View mutations
88 G 0 19 19 0.945 0.964 View mutations
89 V 17 2 19 0.142 0.153 View mutations
90 E 19 0 19 0.030 0.245 View mutations
91 I 19 0 19 0.005 0.301 View mutations
92 S 19 0 19 0.016 0.256 View mutations
93 E 0 19 19 0.914 0.667 View mutations
94 L 19 0 19 0.002 0.477 View mutations
95 G 9 10 19 0.460 0.514 View mutations
96 I 1 18 19 0.935 0.792 View mutations
97 Q 17 2 19 0.091 0.371 View mutations
98 E 10 9 19 0.487 0.498 View mutations
99 F 0 19 19 0.880 0.806 View mutations
100 F 1 18 19 0.922 0.758 View mutations