P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 D 15 4 19 0.223 0.329 View mutations
152 R 0 19 19 1.000 0.797 View mutations
153 G 2 17 19 0.871 0.662 View mutations
154 A 6 13 19 0.653 0.633 View mutations
155 L 1 18 19 0.943 0.841 View mutations
156 V 4 15 19 0.799 0.758 View mutations
157 A 8 11 19 0.628 0.577 View mutations
158 I 1 18 19 0.918 0.896 View mutations
159 N 12 7 19 0.398 0.435 View mutations
160 P 7 12 19 0.594 0.571 View mutations
161 G 9 10 19 0.497 0.431 View mutations
162 D 0 19 19 0.999 0.636 View mutations
163 R 1 18 19 0.936 0.631 View mutations
164 K 11 8 19 0.471 0.483 View mutations
165 C 17 2 19 0.151 0.408 View mutations
166 Y 1 18 19 0.925 0.711 View mutations
167 A 17 2 19 0.108 0.379 View mutations
168 D 5 14 19 0.740 0.402 View mutations
169 T 19 0 19 0.020 0.351 View mutations
170 M 12 7 19 0.341 0.487 View mutations
171 F 18 1 19 0.083 0.485 View mutations
172 S 17 2 19 0.160 0.418 View mutations
173 L 19 0 19 0.002 0.385 View mutations
174 L 19 0 19 0.009 0.541 View mutations
175 G 19 0 19 0.000 0.534 View mutations