Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 E 12 7 19 0.426 0.608 View mutations
77 E 17 2 19 0.139 0.856 View mutations
78 E 5 14 19 0.717 0.295 View mutations
79 P 2 17 19 0.832 0.201 View mutations
80 E 11 8 19 0.569 0.527 View mutations
81 T 14 5 19 0.312 0.629 View mutations
82 D 11 8 19 0.405 0.496 View mutations
83 L 18 1 19 0.085 0.695 View mutations
84 S 19 0 19 0.004 0.707 View mutations
85 P 19 0 19 0.010 0.704 View mutations
86 G 19 0 19 0.000 0.667 View mutations
87 L 17 2 19 0.131 0.446 View mutations
88 P 19 0 19 0.022 0.439 View mutations
89 A 19 0 19 0.020 0.395 View mutations
90 A 19 0 19 0.035 0.381 View mutations
91 H 12 7 19 0.345 0.482 View mutations
92 L 19 0 19 0.001 0.409 View mutations
93 I 18 1 19 0.065 0.470 View mutations
94 G 19 0 19 0.001 0.482 View mutations
95 A 15 4 19 0.335 0.456 View mutations
96 P 19 0 19 0.008 0.591 View mutations
97 L 19 0 19 0.001 0.617 View mutations
98 K 17 2 19 0.159 0.602 View mutations
99 G 18 1 19 0.071 0.498 View mutations
100 Q 16 3 19 0.231 0.463 View mutations