O14521 (SDHD)

Overview
Predicted structure (AF):
AF-O14521-F1-model_v4
Uniprot entry:
O14521
Gene:
SDHD
Protein length:
159 residues
Mutations found:
3020
Benign based on D2Deep prediction:
1994 out of 3020 mutations
Pathogenic based on D2Deep prediction:
1026 out of 3020 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 3020 mutations across 159 unique positions. There are 1994 benign and 1026 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 L 13 6 19 0.351 0.612 View mutations
52 S 17 2 19 0.213 0.693 View mutations
53 P 14 5 19 0.300 0.641 View mutations
54 S 19 0 19 0.004 0.888 View mutations
55 H 19 0 19 0.001 0.911 View mutations
56 H 19 0 19 0.004 0.808 View mutations
57 S 12 7 19 0.389 0.515 View mutations
58 G 19 0 19 0.040 0.453 View mutations
59 S 19 0 19 0.010 0.464 View mutations
60 K 9 10 19 0.498 0.433 View mutations
61 A 8 11 19 0.510 0.511 View mutations
62 A 0 19 19 0.996 0.718 View mutations
63 S 17 2 19 0.137 0.312 View mutations
64 L 16 3 19 0.148 0.404 View mutations
65 H 0 19 19 0.980 0.777 View mutations
66 W 0 19 19 0.987 0.758 View mutations
67 T 2 17 19 0.889 0.628 View mutations
68 S 3 16 19 0.874 0.573 View mutations
69 E 1 18 19 0.916 0.726 View mutations
70 R 3 16 19 0.779 0.718 View mutations
71 V 4 15 19 0.811 0.516 View mutations
72 V 2 17 19 0.838 0.640 View mutations
73 S 0 19 19 0.967 0.797 View mutations
74 V 3 16 19 0.814 0.610 View mutations
75 L 6 13 19 0.692 0.518 View mutations