O14521 (SDHD)

Overview
Predicted structure (AF):
AF-O14521-F1-model_v4
Uniprot entry:
O14521
Gene:
SDHD
Protein length:
159 residues
Mutations found:
3020
Benign based on D2Deep prediction:
1994 out of 3020 mutations
Pathogenic based on D2Deep prediction:
1026 out of 3020 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 3020 mutations across 159 unique positions. There are 1994 benign and 1026 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 L 1 18 19 0.965 0.712 View mutations
77 L 4 15 19 0.765 0.663 View mutations
78 G 0 19 19 0.989 0.590 View mutations
79 L 4 15 19 0.791 0.557 View mutations
80 L 2 17 19 0.865 0.648 View mutations
81 P 0 19 19 1.000 0.751 View mutations
82 A 1 18 19 0.945 0.558 View mutations
83 A 2 17 19 0.893 0.742 View mutations
84 Y 16 3 19 0.239 0.369 View mutations
85 L 13 6 19 0.392 0.481 View mutations
86 N 19 0 19 0.008 0.493 View mutations
87 P 5 14 19 0.782 0.589 View mutations
88 C 9 10 19 0.567 0.503 View mutations
89 S 19 0 19 0.001 0.439 View mutations
90 A 19 0 19 0.001 0.359 View mutations
91 M 17 2 19 0.098 0.478 View mutations
92 D 19 0 19 0.002 0.221 View mutations
93 Y 7 12 19 0.661 0.527 View mutations
94 S 19 0 19 0.037 0.473 View mutations
95 L 3 16 19 0.786 0.630 View mutations
96 A 2 17 19 0.861 0.701 View mutations
97 A 19 0 19 0.010 0.377 View mutations
98 A 19 0 19 0.030 0.396 View mutations
99 L 9 10 19 0.510 0.511 View mutations
100 T 7 12 19 0.620 0.522 View mutations