O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 11 7 18 0.399 0.496 View mutations
2 A 19 0 19 0.019 0.397 View mutations
3 V 9 10 19 0.573 0.502 View mutations
4 P 5 14 19 0.622 0.547 View mutations
5 F 17 2 19 0.232 0.429 View mutations
6 V 18 1 19 0.085 0.399 View mutations
7 E 19 0 19 0.001 0.429 View mutations
8 D 19 0 19 0.010 0.388 View mutations
9 W 6 13 19 0.635 0.554 View mutations
10 D 7 12 19 0.660 0.522 View mutations
11 L 17 2 19 0.103 0.492 View mutations
12 V 5 14 19 0.743 0.523 View mutations
13 Q 18 1 19 0.101 0.415 View mutations
14 T 4 15 19 0.776 0.550 View mutations
15 L 19 0 19 0.025 0.232 View mutations
16 G 19 0 19 0.002 0.312 View mutations
17 E 5 14 19 0.648 0.548 View mutations
18 G 2 17 19 0.876 0.649 View mutations
19 A 5 14 19 0.682 0.548 View mutations
20 Y 9 10 19 0.485 0.503 View mutations
21 G 0 19 19 0.997 0.600 View mutations
22 E 3 16 19 0.786 0.605 View mutations
23 V 0 19 19 1.000 0.704 View mutations
24 Q 0 19 19 0.990 0.578 View mutations
25 L 0 19 19 0.995 0.758 View mutations