O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 A 2 17 19 0.887 0.678 View mutations
27 V 19 0 19 0.036 0.266 View mutations
28 N 17 2 19 0.187 0.409 View mutations
29 R 6 13 19 0.600 0.528 View mutations
30 V 18 1 19 0.063 0.464 View mutations
31 T 18 1 19 0.093 0.326 View mutations
32 E 18 1 19 0.101 0.306 View mutations
33 E 0 19 19 0.969 0.786 View mutations
34 A 19 0 19 0.013 0.185 View mutations
35 V 1 18 19 0.947 0.797 View mutations
36 A 3 16 19 0.849 0.725 View mutations
37 V 5 14 19 0.721 0.597 View mutations
38 K 0 19 19 1.000 0.701 View mutations
39 I 2 17 19 0.909 0.614 View mutations
40 V 3 16 19 0.812 0.631 View mutations
41 D 8 11 19 0.614 0.511 View mutations
42 M 14 5 19 0.326 0.439 View mutations
43 K 19 0 19 0.010 0.447 View mutations
44 R 16 3 19 0.165 0.490 View mutations
45 A 6 13 19 0.764 0.526 View mutations
46 V 17 2 19 0.085 0.484 View mutations
47 D 15 4 19 0.269 0.477 View mutations
48 C 3 16 19 0.775 0.546 View mutations
49 P 16 3 19 0.195 0.435 View mutations
50 E 1 18 19 0.943 0.603 View mutations