O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 N 0 19 19 0.994 0.613 View mutations
52 I 1 18 19 0.952 0.575 View mutations
53 K 2 17 19 0.867 0.588 View mutations
54 K 2 17 19 0.877 0.689 View mutations
55 E 7 12 19 0.568 0.561 View mutations
56 I 12 7 19 0.373 0.457 View mutations
57 C 6 13 19 0.764 0.554 View mutations
58 I 16 3 19 0.154 0.412 View mutations
59 N 13 6 19 0.405 0.487 View mutations
60 K 4 15 19 0.770 0.595 View mutations
61 M 8 11 19 0.545 0.514 View mutations
62 L 2 17 19 0.935 0.634 View mutations
63 N 19 0 19 0.039 0.409 View mutations
64 H 19 0 19 0.024 0.401 View mutations
65 E 19 0 19 0.002 0.429 View mutations
66 N 16 3 19 0.196 0.436 View mutations
67 V 1 18 19 0.941 0.698 View mutations
68 V 1 18 19 0.942 0.697 View mutations
69 K 19 0 19 0.002 0.368 View mutations
70 F 11 8 19 0.426 0.479 View mutations
71 Y 1 18 19 0.923 0.695 View mutations
72 G 1 18 19 0.943 0.775 View mutations
73 H 4 15 19 0.785 0.557 View mutations
74 R 1 18 19 0.929 0.661 View mutations
75 R 9 10 19 0.539 0.503 View mutations