O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
451 F 19 0 19 0.016 0.130 View mutations
452 K 6 13 19 0.742 0.626 View mutations
453 R 14 5 19 0.245 0.399 View mutations
454 H 19 0 19 0.001 0.344 View mutations
455 F 15 4 19 0.212 0.291 View mutations
456 L 6 13 19 0.681 0.567 View mutations
457 K 17 2 19 0.147 0.444 View mutations
458 I 13 6 19 0.325 0.413 View mutations
459 K 9 10 19 0.501 0.510 View mutations
460 G 19 0 19 0.007 0.472 View mutations
461 K 19 0 19 0.001 0.489 View mutations
462 L 15 4 19 0.205 0.430 View mutations
463 I 16 3 19 0.137 0.427 View mutations
464 D 19 0 19 0.018 0.384 View mutations
465 I 17 2 19 0.082 0.462 View mutations
466 V 19 0 19 0.006 0.439 View mutations
467 S 17 2 19 0.124 0.375 View mutations
468 S 19 0 19 0.004 0.495 View mutations
469 Q 12 7 19 0.356 0.436 View mutations
470 K 9 10 19 0.546 0.434 View mutations
471 I 14 5 19 0.322 0.451 View mutations
472 W 19 0 19 0.000 0.590 View mutations
473 L 19 0 19 0.000 0.564 View mutations
474 P 19 0 19 0.000 0.481 View mutations
475 A 18 1 19 0.056 0.606 View mutations