O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
426 F 11 8 19 0.433 0.466 View mutations
427 K 1 18 19 0.946 0.699 View mutations
428 V 2 17 19 0.903 0.745 View mutations
429 N 16 3 19 0.218 0.405 View mutations
430 L 17 2 19 0.114 0.402 View mutations
431 L 19 0 19 0.051 0.313 View mutations
432 E 15 4 19 0.172 0.379 View mutations
433 M 19 0 19 0.005 0.357 View mutations
434 D 16 3 19 0.218 0.412 View mutations
435 D 19 0 19 0.001 0.421 View mutations
436 K 19 0 19 0.000 0.419 View mutations
437 I 15 4 19 0.201 0.426 View mutations
438 L 1 18 19 0.910 0.809 View mutations
439 V 10 9 19 0.479 0.486 View mutations
440 D 0 19 19 1.000 0.932 View mutations
441 F 0 19 19 0.982 0.745 View mutations
442 R 15 4 19 0.235 0.221 View mutations
443 L 13 6 19 0.315 0.347 View mutations
444 S 4 15 19 0.789 0.762 View mutations
445 K 8 11 19 0.511 0.556 View mutations
446 G 14 5 19 0.295 0.288 View mutations
447 D 9 10 19 0.595 0.522 View mutations
448 G 10 9 19 0.431 0.476 View mutations
449 L 2 17 19 0.840 0.737 View mutations
450 E 2 17 19 0.905 0.751 View mutations