O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
401 G 8 11 19 0.600 0.504 View mutations
402 Y 16 3 19 0.215 0.479 View mutations
403 Q 19 0 19 0.000 0.424 View mutations
404 W 4 15 19 0.821 0.423 View mutations
405 K 19 0 19 0.000 0.447 View mutations
406 K 19 0 19 0.002 0.483 View mutations
407 S 19 0 19 0.016 0.432 View mutations
408 C 13 6 19 0.318 0.419 View mutations
409 M 19 0 19 0.001 0.443 View mutations
410 N 11 8 19 0.506 0.418 View mutations
411 Q 13 6 19 0.379 0.484 View mutations
412 V 1 18 19 0.946 0.524 View mutations
413 T 5 14 19 0.737 0.577 View mutations
414 I 5 14 19 0.693 0.569 View mutations
415 S 19 0 19 0.000 0.352 View mutations
416 T 0 19 19 0.994 0.643 View mutations
417 T 16 3 19 0.185 0.427 View mutations
418 D 1 18 19 0.925 0.764 View mutations
419 R 18 1 19 0.047 0.293 View mutations
420 R 0 19 19 0.996 0.785 View mutations
421 N 18 1 19 0.089 0.288 View mutations
422 N 17 2 19 0.080 0.336 View mutations
423 K 13 6 19 0.341 0.429 View mutations
424 L 5 14 19 0.733 0.630 View mutations
425 I 18 1 19 0.030 0.305 View mutations