O14757 (CHEK1)

Overview
Predicted structure (AF):
AF-O14757-F1-model_v4
Uniprot entry:
O14757
Gene:
CHEK1
Protein length:
476 residues
Mutations found:
9043
Benign based on D2Deep prediction:
5640 out of 9043 mutations
Pathogenic based on D2Deep prediction:
3403 out of 9043 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9043 mutations across 476 unique positions. There are 5640 benign and 3403 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 E 12 7 19 0.402 0.472 View mutations
77 G 19 0 19 0.081 0.406 View mutations
78 N 10 9 19 0.445 0.437 View mutations
79 I 15 4 19 0.255 0.494 View mutations
80 Q 2 17 19 0.904 0.519 View mutations
81 Y 1 18 19 0.947 0.615 View mutations
82 L 1 18 19 0.947 0.691 View mutations
83 F 0 19 19 0.971 0.712 View mutations
84 L 13 6 19 0.310 0.398 View mutations
85 E 19 0 19 0.040 0.281 View mutations
86 Y 19 0 19 0.011 0.222 View mutations
87 C 3 16 19 0.847 0.674 View mutations
88 S 13 6 19 0.359 0.419 View mutations
89 G 19 0 19 0.048 0.109 View mutations
90 G 19 0 19 0.008 0.013 View mutations
91 E 13 6 19 0.344 0.342 View mutations
92 L 19 0 19 0.001 0.037 View mutations
93 F 1 18 19 0.932 0.815 View mutations
94 D 6 13 19 0.571 0.675 View mutations
95 R 3 16 19 0.791 0.743 View mutations
96 I 10 9 19 0.536 0.478 View mutations
97 E 15 4 19 0.305 0.309 View mutations
98 P 4 15 19 0.780 0.690 View mutations
99 D 12 7 19 0.408 0.419 View mutations
100 I 6 13 19 0.638 0.582 View mutations