O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 T 3 16 19 0.819 0.616 View mutations
127 R 9 10 19 0.616 0.509 View mutations
128 R 1 18 19 0.805 0.573 View mutations
129 Y 7 12 19 0.611 0.507 View mutations
130 A 5 14 19 0.708 0.532 View mutations
131 F 4 15 19 0.772 0.525 View mutations
132 A 9 10 19 0.513 0.507 View mutations
133 H 16 3 19 0.198 0.471 View mutations
134 I 9 10 19 0.554 0.504 View mutations
135 L 17 2 19 0.205 0.496 View mutations
136 T 18 1 19 0.111 0.417 View mutations
137 V 18 1 19 0.165 0.489 View mutations
138 L 17 2 19 0.116 0.498 View mutations
139 Q 19 0 19 0.105 0.380 View mutations
140 C 15 4 19 0.201 0.476 View mutations
141 A 10 9 19 0.470 0.492 View mutations
142 T 19 0 19 0.035 0.375 View mutations
143 V 19 0 19 0.007 0.370 View mutations
144 I 19 0 19 0.036 0.354 View mutations
145 G 19 0 19 0.071 0.268 View mutations
146 F 19 0 19 0.066 0.311 View mutations
147 S 18 1 19 0.094 0.356 View mutations
148 Y 18 1 19 0.174 0.280 View mutations
149 W 18 1 19 0.178 0.300 View mutations
150 A 19 0 19 0.075 0.239 View mutations