P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
276 F 1 18 19 0.912 0.607 View mutations
277 R 18 1 19 0.054 0.409 View mutations
278 M 19 0 19 0.001 0.393 View mutations
279 T 13 6 19 0.336 0.439 View mutations
280 D 13 6 19 0.274 0.448 View mutations
281 Q 2 17 19 0.876 0.615 View mutations
282 E 19 0 19 0.042 0.351 View mutations
283 A 18 1 19 0.091 0.348 View mutations
284 I 2 17 19 0.898 0.660 View mutations
285 Q 11 8 19 0.458 0.488 View mutations
286 D 19 0 19 0.019 0.418 View mutations
287 L 9 10 19 0.519 0.512 View mutations
288 W 2 17 19 0.892 0.635 View mutations
289 Q 18 1 19 0.065 0.482 View mutations
290 W 3 16 19 0.854 0.524 View mutations
291 R 8 11 19 0.599 0.437 View mutations
292 K 4 15 19 0.762 0.527 View mutations
293 S 19 0 19 0.001 0.414 View mutations
294 L 10 9 19 0.472 0.492 View mutations