P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 17 1 18 0.103 0.321 View mutations
2 E 19 0 19 0.061 0.369 View mutations
3 D 2 17 19 0.908 0.584 View mutations
4 S 17 2 19 0.086 0.454 View mutations
5 M 18 1 19 0.096 0.444 View mutations
6 D 19 0 19 0.042 0.384 View mutations
7 M 19 0 19 0.000 0.372 View mutations
8 D 19 0 19 0.001 0.470 View mutations
9 M 19 0 19 0.038 0.427 View mutations
10 S 19 0 19 0.009 0.406 View mutations
11 P 19 0 19 0.000 0.294 View mutations
12 L 16 3 19 0.221 0.381 View mutations
13 R 19 0 19 0.013 0.372 View mutations
14 P 18 1 19 0.101 0.360 View mutations
15 Q 19 0 19 0.009 0.357 View mutations
16 N 19 0 19 0.001 0.388 View mutations
17 Y 19 0 19 0.022 0.437 View mutations
18 L 7 12 19 0.666 0.529 View mutations
19 F 15 4 19 0.162 0.457 View mutations
20 G 19 0 19 0.006 0.300 View mutations
21 C 0 19 19 0.947 0.724 View mutations
22 E 16 3 19 0.175 0.319 View mutations
23 L 1 18 19 0.947 0.725 View mutations
24 K 12 7 19 0.379 0.472 View mutations
25 A 8 11 19 0.534 0.530 View mutations