P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 M 10 9 19 0.524 0.496 View mutations
252 Q 18 1 19 0.090 0.413 View mutations
253 A 9 10 19 0.471 0.508 View mutations
254 S 19 0 19 0.004 0.468 View mutations
255 I 12 7 19 0.418 0.479 View mutations
256 E 7 12 19 0.676 0.549 View mutations
257 K 4 15 19 0.737 0.570 View mutations
258 G 18 1 19 0.131 0.462 View mutations
259 G 19 0 19 0.011 0.438 View mutations
260 S 19 0 19 0.000 0.361 View mutations
261 L 7 12 19 0.612 0.535 View mutations
262 P 0 19 19 0.999 0.606 View mutations
263 K 19 0 19 0.006 0.436 View mutations
264 V 11 8 19 0.385 0.498 View mutations
265 E 14 5 19 0.318 0.434 View mutations
266 A 19 0 19 0.001 0.405 View mutations
267 K 0 19 19 0.994 0.576 View mutations
268 F 3 16 19 0.831 0.556 View mutations
269 I 7 12 19 0.618 0.522 View mutations
270 N 2 17 19 0.820 0.604 View mutations
271 Y 5 14 19 0.700 0.529 View mutations
272 V 19 0 19 0.008 0.362 View mutations
273 K 2 17 19 0.869 0.565 View mutations
274 N 2 17 19 0.902 0.587 View mutations
275 C 17 2 19 0.109 0.456 View mutations