P06748 (NPM1)

Overview
Predicted structure (AF):
AF-P06748-F1-model_v4
Uniprot entry:
P06748
Gene:
NPM1
Protein length:
294 residues
Mutations found:
5585
Benign based on D2Deep prediction:
4154 out of 5585 mutations
Pathogenic based on D2Deep prediction:
1431 out of 5585 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5585 mutations across 294 unique positions. There are 4154 benign and 1431 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 E 18 1 19 0.052 0.597 View mutations
227 S 19 0 19 0.003 0.671 View mutations
228 F 18 1 19 0.055 0.659 View mutations
229 K 11 8 19 0.491 0.501 View mutations
230 K 19 0 19 0.019 0.663 View mutations
231 Q 18 1 19 0.040 0.621 View mutations
232 E 14 5 19 0.334 0.489 View mutations
233 K 5 14 19 0.670 0.366 View mutations
234 T 10 9 19 0.494 0.449 View mutations
235 P 18 1 19 0.116 0.389 View mutations
236 K 19 0 19 0.009 0.556 View mutations
237 T 15 4 19 0.239 0.432 View mutations
238 P 2 17 19 0.848 0.519 View mutations
239 K 12 7 19 0.382 0.428 View mutations
240 G 19 0 19 0.002 0.371 View mutations
241 P 19 0 19 0.000 0.420 View mutations
242 S 19 0 19 0.028 0.412 View mutations
243 S 19 0 19 0.027 0.457 View mutations
244 V 19 0 19 0.000 0.389 View mutations
245 E 11 8 19 0.397 0.476 View mutations
246 D 11 8 19 0.380 0.474 View mutations
247 I 18 1 19 0.098 0.351 View mutations
248 K 7 12 19 0.628 0.526 View mutations
249 A 4 15 19 0.755 0.621 View mutations
250 K 7 12 19 0.625 0.521 View mutations