P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 V 4 15 19 0.771 0.644 View mutations
177 T 0 19 19 0.993 0.831 View mutations
178 L 11 8 19 0.495 0.467 View mutations
179 W 2 17 19 0.849 0.676 View mutations
180 Y 0 19 19 1.000 0.872 View mutations
181 R 6 13 19 0.717 0.638 View mutations
182 A 3 16 19 0.846 0.715 View mutations
183 P 3 16 19 0.852 0.801 View mutations
184 E 0 19 19 1.000 0.816 View mutations
185 V 15 4 19 0.208 0.356 View mutations
186 L 18 1 19 0.046 0.294 View mutations
187 L 10 9 19 0.513 0.490 View mutations
188 Q 19 0 19 0.011 0.374 View mutations
189 S 15 4 19 0.262 0.491 View mutations
190 T 19 0 19 0.000 0.462 View mutations
191 Y 2 17 19 0.812 0.690 View mutations
192 A 13 6 19 0.354 0.448 View mutations
193 T 17 2 19 0.171 0.372 View mutations
194 P 14 5 19 0.248 0.439 View mutations
195 V 18 1 19 0.096 0.271 View mutations
196 D 19 0 19 0.081 0.146 View mutations
197 M 19 0 19 0.000 0.361 View mutations
198 W 1 18 19 0.949 0.714 View mutations
199 S 14 5 19 0.274 0.350 View mutations
200 V 6 13 19 0.714 0.505 View mutations