P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 R 19 0 19 0.023 0.612 View mutations
127 G 0 19 19 0.970 0.727 View mutations
128 L 1 18 19 0.962 0.757 View mutations
129 D 17 2 19 0.113 0.392 View mutations
130 F 0 19 19 1.000 0.709 View mutations
131 L 0 19 19 1.000 0.824 View mutations
132 H 0 19 19 1.000 0.797 View mutations
133 A 9 10 19 0.557 0.437 View mutations
134 N 2 17 19 0.900 0.553 View mutations
135 C 13 6 19 0.297 0.466 View mutations
136 I 3 16 19 0.864 0.607 View mutations
137 V 3 16 19 0.839 0.648 View mutations
138 H 0 19 19 0.987 0.849 View mutations
139 R 0 19 19 0.968 0.855 View mutations
140 D 0 19 19 0.998 0.889 View mutations
141 L 0 19 19 0.993 0.864 View mutations
142 K 19 0 19 0.041 0.000 View mutations
143 P 19 0 19 0.001 0.127 View mutations
144 E 17 2 19 0.172 0.410 View mutations
145 N 19 0 19 0.006 0.100 View mutations
146 I 19 0 19 0.000 0.243 View mutations
147 L 2 17 19 0.857 0.766 View mutations
148 V 19 0 19 0.001 0.304 View mutations
149 T 17 2 19 0.173 0.478 View mutations
150 S 19 0 19 0.000 0.403 View mutations