P16422 (EPCAM)

Overview
Predicted structure (AF):
AF-P16422-F1-model_v4
Uniprot entry:
P16422
Gene:
EPCAM
Protein length:
314 residues
Mutations found:
5965
Benign based on D2Deep prediction:
3951 out of 5965 mutations
Pathogenic based on D2Deep prediction:
2014 out of 5965 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5965 mutations across 314 unique positions. There are 3951 benign and 2014 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 Y 1 18 19 0.946 0.638 View mutations
252 V 7 12 19 0.656 0.537 View mutations
253 D 1 18 19 0.967 0.628 View mutations
254 E 9 10 19 0.510 0.505 View mutations
255 K 8 11 19 0.536 0.436 View mutations
256 A 2 17 19 0.871 0.570 View mutations
257 P 0 19 19 0.992 0.633 View mutations
258 E 10 9 19 0.509 0.498 View mutations
259 F 6 13 19 0.693 0.451 View mutations
260 S 13 6 19 0.304 0.424 View mutations
261 M 5 14 19 0.760 0.413 View mutations
262 Q 0 19 19 0.975 0.302 View mutations
263 G 16 3 19 0.251 0.501 View mutations
264 L 4 15 19 0.783 0.396 View mutations
265 K 11 8 19 0.442 0.483 View mutations
266 A 15 4 19 0.334 0.491 View mutations
267 G 0 19 19 0.993 0.436 View mutations
268 V 6 13 19 0.663 0.400 View mutations
269 I 0 19 19 0.908 0.351 View mutations
270 A 1 18 19 0.927 0.417 View mutations
271 V 1 18 19 0.943 0.417 View mutations
272 I 8 11 19 0.571 0.430 View mutations
273 V 8 11 19 0.535 0.431 View mutations
274 V 1 18 19 0.948 0.401 View mutations
275 V 7 12 19 0.612 0.418 View mutations