P21912 (SDHB)

Overview
Predicted structure (AF):
AF-P21912-F1-model_v4
Uniprot entry:
P21912
Gene:
SDHB
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
3093 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2226 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 3093 benign and 2226 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 K 19 0 19 0.011 0.577 View mutations
152 S 9 10 19 0.499 0.433 View mutations
153 I 11 8 19 0.397 0.490 View mutations
154 E 19 0 19 0.037 0.511 View mutations
155 P 5 14 19 0.739 0.545 View mutations
156 Y 13 6 19 0.324 0.498 View mutations
157 L 19 0 19 0.043 0.493 View mutations
158 K 19 0 19 0.002 0.672 View mutations
159 K 19 0 19 0.001 0.710 View mutations
160 K 19 0 19 0.003 0.685 View mutations
161 D 19 0 19 0.013 0.696 View mutations
162 E 18 1 19 0.066 0.660 View mutations
163 S 19 0 19 0.007 0.720 View mutations
164 Q 19 0 19 0.005 0.705 View mutations
165 E 19 0 19 0.003 0.725 View mutations
166 G 19 0 19 0.006 0.710 View mutations
167 K 19 0 19 0.003 0.740 View mutations
168 Q 19 0 19 0.012 0.701 View mutations
169 Q 19 0 19 0.001 0.414 View mutations
170 Y 19 0 19 0.001 0.534 View mutations
171 L 18 1 19 0.128 0.444 View mutations
172 Q 17 2 19 0.175 0.423 View mutations
173 S 19 0 19 0.007 0.436 View mutations
174 I 19 0 19 0.002 0.552 View mutations
175 E 19 0 19 0.005 0.633 View mutations