P25445 (P25445)

Overview
Predicted structure (AF):
AF-P25445-F1-model_v4
Uniprot entry:
P25445
Gene:
P25445
Protein length:
335 residues
Mutations found:
6364
Benign based on D2Deep prediction:
4666 out of 6364 mutations
Pathogenic based on D2Deep prediction:
1698 out of 6364 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6364 mutations across 335 unique positions. There are 4666 benign and 1698 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
276 Q 0 19 19 0.987 0.797 View mutations
277 L 1 18 19 0.916 0.883 View mutations
278 L 2 17 19 0.905 0.895 View mutations
279 R 1 18 19 0.920 0.784 View mutations
280 N 2 17 19 0.911 0.582 View mutations
281 W 0 19 19 0.986 0.897 View mutations
282 H 13 6 19 0.278 0.354 View mutations
283 Q 10 9 19 0.458 0.488 View mutations
284 L 5 14 19 0.737 0.587 View mutations
285 H 9 10 19 0.523 0.514 View mutations
286 G 15 4 19 0.234 0.276 View mutations
287 K 18 1 19 0.094 0.296 View mutations
288 K 17 2 19 0.120 0.416 View mutations
289 E 18 1 19 0.036 0.368 View mutations
290 A 16 3 19 0.157 0.254 View mutations
291 Y 11 8 19 0.409 0.471 View mutations
292 D 18 1 19 0.044 0.443 View mutations
293 T 19 0 19 0.000 0.361 View mutations
294 L 15 4 19 0.224 0.318 View mutations
295 I 19 0 19 0.005 0.427 View mutations
296 K 19 0 19 0.000 0.456 View mutations
297 D 15 4 19 0.238 0.459 View mutations
298 L 9 10 19 0.494 0.512 View mutations
299 K 18 1 19 0.066 0.394 View mutations
300 K 19 0 19 0.051 0.499 View mutations