P25445 (P25445)

Overview
Predicted structure (AF):
AF-P25445-F1-model_v4
Uniprot entry:
P25445
Gene:
P25445
Protein length:
335 residues
Mutations found:
6364
Benign based on D2Deep prediction:
4666 out of 6364 mutations
Pathogenic based on D2Deep prediction:
1698 out of 6364 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6364 mutations across 335 unique positions. There are 4666 benign and 1698 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 D 16 3 19 0.269 0.388 View mutations
227 V 18 1 19 0.028 0.390 View mutations
228 D 2 17 19 0.879 0.483 View mutations
229 L 0 19 19 0.997 0.574 View mutations
230 S 8 11 19 0.639 0.505 View mutations
231 K 19 0 19 0.035 0.439 View mutations
232 Y 1 18 19 0.934 0.524 View mutations
233 I 0 19 19 0.998 0.660 View mutations
234 T 6 13 19 0.683 0.511 View mutations
235 T 18 1 19 0.058 0.498 View mutations
236 I 5 14 19 0.747 0.577 View mutations
237 A 12 7 19 0.412 0.455 View mutations
238 G 7 12 19 0.569 0.527 View mutations
239 V 15 4 19 0.268 0.386 View mutations
240 M 8 11 19 0.583 0.532 View mutations
241 T 12 7 19 0.364 0.460 View mutations
242 L 8 11 19 0.534 0.524 View mutations
243 S 19 0 19 0.012 0.450 View mutations
244 Q 18 1 19 0.135 0.439 View mutations
245 V 2 17 19 0.908 0.722 View mutations
246 K 3 16 19 0.761 0.590 View mutations
247 G 19 0 19 0.021 0.446 View mutations
248 F 8 11 19 0.584 0.535 View mutations
249 V 2 17 19 0.902 0.827 View mutations
250 R 0 19 19 0.996 0.834 View mutations