P25445 (P25445)

Overview
Predicted structure (AF):
AF-P25445-F1-model_v4
Uniprot entry:
P25445
Gene:
P25445
Protein length:
335 residues
Mutations found:
6364
Benign based on D2Deep prediction:
4666 out of 6364 mutations
Pathogenic based on D2Deep prediction:
1698 out of 6364 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6364 mutations across 335 unique positions. There are 4666 benign and 1698 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 K 14 5 19 0.374 0.466 View mutations
252 N 8 11 19 0.594 0.533 View mutations
253 G 0 19 19 0.955 0.836 View mutations
254 V 1 18 19 0.948 0.693 View mutations
255 N 6 13 19 0.661 0.575 View mutations
256 E 6 13 19 0.671 0.616 View mutations
257 A 12 7 19 0.449 0.436 View mutations
258 K 0 19 19 0.983 0.657 View mutations
259 I 3 16 19 0.843 0.792 View mutations
260 D 2 17 19 0.910 0.733 View mutations
261 E 3 16 19 0.841 0.657 View mutations
262 I 0 19 19 1.000 0.832 View mutations
263 K 15 4 19 0.207 0.388 View mutations
264 N 16 3 19 0.215 0.420 View mutations
265 D 6 13 19 0.654 0.563 View mutations
266 N 8 11 19 0.550 0.514 View mutations
267 V 4 15 19 0.707 0.581 View mutations
268 Q 16 3 19 0.212 0.420 View mutations
269 D 2 17 19 0.907 0.682 View mutations
270 T 0 19 19 0.970 0.829 View mutations
271 A 11 8 19 0.363 0.442 View mutations
272 E 2 17 19 0.884 0.776 View mutations
273 Q 4 15 19 0.809 0.747 View mutations
274 K 0 19 19 0.996 0.863 View mutations
275 V 7 12 19 0.591 0.565 View mutations