P31749 (AKT1)

Overview
Predicted structure (AF):
AF-P31749-F1-model_v4
Uniprot entry:
P31749
Gene:
AKT1
Protein length:
480 residues
Mutations found:
9119
Benign based on D2Deep prediction:
5131 out of 9119 mutations
Pathogenic based on D2Deep prediction:
3988 out of 9119 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9119 mutations across 480 unique positions. There are 5131 benign and 3988 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
426 K 19 0 19 0.028 0.472 View mutations
427 P 1 18 19 0.948 0.547 View mutations
428 Q 10 9 19 0.494 0.441 View mutations
429 V 19 0 19 0.149 0.389 View mutations
430 T 19 0 19 0.002 0.502 View mutations
431 S 19 0 19 0.006 0.434 View mutations
432 E 19 0 19 0.035 0.404 View mutations
433 T 19 0 19 0.000 0.471 View mutations
434 D 2 17 19 0.876 0.480 View mutations
435 T 19 0 19 0.019 0.414 View mutations
436 R 19 0 19 0.000 0.403 View mutations
437 Y 19 0 19 0.000 0.457 View mutations
438 F 2 17 19 0.862 0.525 View mutations
439 D 13 6 19 0.324 0.421 View mutations
440 E 7 12 19 0.622 0.421 View mutations
441 E 0 19 19 0.982 0.468 View mutations
442 F 19 0 19 0.001 0.472 View mutations
443 T 19 0 19 0.002 0.351 View mutations
444 A 12 7 19 0.420 0.446 View mutations
445 Q 19 0 19 0.013 0.493 View mutations
446 M 19 0 19 0.000 0.453 View mutations
447 I 18 1 19 0.056 0.404 View mutations
448 T 19 0 19 0.033 0.445 View mutations
449 I 15 4 19 0.242 0.483 View mutations
450 T 19 0 19 0.048 0.444 View mutations