P31749 (AKT1)

Overview
Predicted structure (AF):
AF-P31749-F1-model_v4
Uniprot entry:
P31749
Gene:
AKT1
Protein length:
480 residues
Mutations found:
9119
Benign based on D2Deep prediction:
5131 out of 9119 mutations
Pathogenic based on D2Deep prediction:
3988 out of 9119 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9119 mutations across 480 unique positions. There are 5131 benign and 3988 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
376 A 15 4 19 0.236 0.490 View mutations
377 K 11 8 19 0.375 0.426 View mutations
378 S 8 11 19 0.584 0.432 View mutations
379 L 11 8 19 0.436 0.494 View mutations
380 L 0 19 19 0.958 0.761 View mutations
381 S 15 4 19 0.216 0.398 View mutations
382 G 0 19 19 0.998 0.551 View mutations
383 L 0 19 19 0.995 0.656 View mutations
384 L 18 1 19 0.054 0.308 View mutations
385 K 18 1 19 0.077 0.492 View mutations
386 K 4 15 19 0.789 0.553 View mutations
387 D 18 1 19 0.101 0.374 View mutations
388 P 19 0 19 0.000 0.381 View mutations
389 K 15 4 19 0.211 0.488 View mutations
390 Q 19 0 19 0.000 0.512 View mutations
391 R 7 12 19 0.603 0.523 View mutations
392 L 17 2 19 0.172 0.449 View mutations
393 G 2 17 19 0.897 0.461 View mutations
394 G 13 6 19 0.387 0.401 View mutations
395 G 19 0 19 0.000 0.361 View mutations
396 S 19 0 19 0.001 0.531 View mutations
397 E 19 0 19 0.006 0.645 View mutations
398 D 18 1 19 0.076 0.484 View mutations
399 A 19 0 19 0.004 0.515 View mutations
400 K 19 0 19 0.005 0.688 View mutations