P31749 (AKT1)

Overview
Predicted structure (AF):
AF-P31749-F1-model_v4
Uniprot entry:
P31749
Gene:
AKT1
Protein length:
480 residues
Mutations found:
9119
Benign based on D2Deep prediction:
5131 out of 9119 mutations
Pathogenic based on D2Deep prediction:
3988 out of 9119 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9119 mutations across 480 unique positions. There are 5131 benign and 3988 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
401 E 15 4 19 0.275 0.514 View mutations
402 I 13 6 19 0.301 0.399 View mutations
403 M 19 0 19 0.000 0.620 View mutations
404 Q 17 2 19 0.124 0.621 View mutations
405 H 16 3 19 0.138 0.432 View mutations
406 R 19 0 19 0.006 0.550 View mutations
407 F 19 0 19 0.014 0.449 View mutations
408 F 0 19 19 0.977 0.384 View mutations
409 A 19 0 19 0.001 0.706 View mutations
410 G 17 2 19 0.154 0.574 View mutations
411 I 11 8 19 0.422 0.470 View mutations
412 V 13 6 19 0.303 0.565 View mutations
413 W 0 19 19 0.999 0.311 View mutations
414 Q 18 1 19 0.057 0.648 View mutations
415 H 16 3 19 0.176 0.648 View mutations
416 V 1 18 19 0.913 0.430 View mutations
417 Y 12 7 19 0.395 0.503 View mutations
418 E 16 3 19 0.149 0.641 View mutations
419 K 15 4 19 0.149 0.488 View mutations
420 K 3 16 19 0.794 0.347 View mutations
421 L 18 1 19 0.081 0.583 View mutations
422 S 19 0 19 0.011 0.692 View mutations
423 P 3 16 19 0.863 0.444 View mutations
424 P 9 10 19 0.562 0.431 View mutations
425 F 18 1 19 0.106 0.436 View mutations