P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 F 0 19 19 0.974 0.784 View mutations
77 C 13 6 19 0.363 0.431 View mutations
78 N 0 19 19 0.997 0.881 View mutations
79 R 9 10 19 0.571 0.515 View mutations
80 S 0 19 19 0.999 0.904 View mutations
81 P 0 19 19 0.991 0.841 View mutations
82 R 0 19 19 1.000 0.693 View mutations
83 V 1 18 19 0.837 0.573 View mutations
84 V 10 9 19 0.553 0.483 View mutations
85 L 19 0 19 0.033 0.392 View mutations
86 P 17 2 19 0.195 0.280 View mutations
87 V 17 2 19 0.143 0.366 View mutations
88 W 17 2 19 0.241 0.339 View mutations
89 L 14 5 19 0.285 0.346 View mutations
90 N 17 2 19 0.145 0.361 View mutations
91 F 19 0 19 0.001 0.202 View mutations
92 D 19 0 19 0.000 0.290 View mutations
93 G 19 0 19 0.017 0.142 View mutations
94 E 19 0 19 0.047 0.342 View mutations
95 P 10 9 19 0.465 0.490 View mutations
96 Q 16 3 19 0.239 0.434 View mutations
97 P 19 0 19 0.008 0.337 View mutations
98 Y 19 0 19 0.061 0.313 View mutations
99 P 19 0 19 0.014 0.355 View mutations
100 T 14 5 19 0.284 0.488 View mutations