P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
126 D 0 19 19 0.948 0.690 View mutations
127 G 3 16 19 0.783 0.552 View mutations
128 L 0 19 19 0.973 0.720 View mutations
129 L 1 18 19 0.955 0.699 View mutations
130 V 0 19 19 0.996 0.732 View mutations
131 N 0 19 19 0.933 0.636 View mutations
132 Q 1 18 19 0.908 0.623 View mutations
133 T 8 11 19 0.550 0.529 View mutations
134 E 1 18 19 0.921 0.704 View mutations
135 L 11 8 19 0.443 0.468 View mutations
136 F 3 16 19 0.698 0.635 View mutations
137 V 6 13 19 0.584 0.563 View mutations
138 P 9 10 19 0.505 0.511 View mutations
139 S 19 0 19 0.087 0.325 View mutations
140 L 13 6 19 0.323 0.468 View mutations
141 N 18 1 19 0.128 0.459 View mutations
142 V 19 0 19 0.019 0.345 View mutations
143 D 19 0 19 0.002 0.373 View mutations
144 G 18 1 19 0.091 0.337 View mutations
145 Q 18 1 19 0.055 0.358 View mutations
146 P 19 0 19 0.003 0.379 View mutations
147 I 13 6 19 0.274 0.468 View mutations
148 F 19 0 19 0.002 0.378 View mutations
149 A 19 0 19 0.020 0.312 View mutations
150 N 18 1 19 0.075 0.415 View mutations