P42772 (CDKN2B)

Overview
Predicted structure (AF):
AF-P42772-F1-model_v4
Uniprot entry:
P42772
Gene:
CDKN2B
Protein length:
138 residues
Mutations found:
2621
Benign based on D2Deep prediction:
1462 out of 2621 mutations
Pathogenic based on D2Deep prediction:
1159 out of 2621 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 2621 mutations across 138 unique positions. There are 1462 benign and 1159 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 I 0 19 19 0.981 0.591 View mutations
52 Q 0 19 19 0.996 0.685 View mutations
53 V 0 19 19 0.995 0.729 View mutations
54 M 2 17 19 0.847 0.544 View mutations
55 M 16 3 19 0.202 0.384 View mutations
56 M 5 14 19 0.757 0.653 View mutations
57 G 3 16 19 0.846 0.661 View mutations
58 S 6 13 19 0.722 0.451 View mutations
59 A 19 0 19 0.000 0.358 View mutations
60 R 12 7 19 0.395 0.502 View mutations
61 V 4 15 19 0.785 0.515 View mutations
62 A 0 19 19 1.000 0.815 View mutations
63 E 18 1 19 0.059 0.410 View mutations
64 L 7 12 19 0.581 0.429 View mutations
65 L 0 19 19 0.994 0.766 View mutations
66 L 0 19 19 1.000 0.750 View mutations
67 L 12 7 19 0.392 0.445 View mutations
68 H 11 8 19 0.404 0.437 View mutations
69 G 13 6 19 0.339 0.337 View mutations
70 A 7 12 19 0.635 0.608 View mutations
71 E 5 14 19 0.740 0.557 View mutations
72 P 0 19 19 0.965 0.767 View mutations
73 N 0 19 19 1.000 0.661 View mutations
74 C 11 8 19 0.517 0.419 View mutations
75 A 5 14 19 0.656 0.542 View mutations